Although there has been some controversy over microhemorrhages in the SOD1 mice, using post-mortem tissue from ALS patients compared with non-neurodegenerative controls, attesting to the BBB, or more specifically blood–spinal cord barrier (BSCB) breakdown, they found perivascular deposits of erythrocyte-derived hemoglobin and hemosiderin, suggestive of erythrocyte extravasation [110]. Here, SOD1 is linked to amyotrophic lateral sclerosis.