HMGB1 and amyotrophic lateral sclerosis: Relevant to ALS, HMGB1 levels were found to be elevated in spinal cord tissue of SOD1-G93A transgenic mice, as well as other proteins associated with HMGB1 pathways such as TLR2/4 and serine/threonine kinase 30, the latter being an ortholog of RAGE [51].