SOD1 and amyotrophic lateral sclerosis: In addition, a long history of BBB dysfunction in ALS patients had been previously reviewed [97]; however, in the “modern era”, Garbuzova-Davis and colleagues at the University of South Florida began to study BBB integrity in transgenic SOD1 mice in the early 2000s, finding evidence of BBB and blood–spinal cord barrier (BSCB) dysfunction both in this ALS model as well as in patients with ALS [98,99,100].