In another study, two G-CSF rounds, each including 10 days of injections, were used to treat progressive amyotrophic lateral sclerosis and shown to be safe; although there was no significant clinical improvement after G-CSF treatment, the group injected with G-CSF showed amelioration of structural neural damage within 1 month [16]. Here, CSF3 is linked to amyotrophic lateral sclerosis.