PRKN and Parkinson disease: Furthermore, Mfn2 gates the autophagic turnover of mitochondria by PINK1 and Parkin, and PD-related LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of LRRK2 substrate indicating that Mfn2, LRRK2, PINK1, and Parkin all converge on a common pathway of mitophagy [63,64,65].