At the same time, mitochondrial fission/fusion alterations, including Mfn1, Mfn2, optic atrophy 1 (Opa1), dynamin-related protein 1 (Drp1), mitochondrial movements, and mitochondrial Ca2+ handling are affected in HD and have been well investigated and described [71,72,73,74,75,76,77,78]. The gene discussed is DNM1L; the disease is Huntington disease.