AQP4 and epilepsy: It is worth adding that in light of recent research, this is most probably due to the effect of the drug at the astrocytes in the tripartite synapse where aquaporin 4 (AQP4) channels, which are mainly expressed in perivascular astrocyte endfeet, have been shown to play a major role in cell swelling and in the pathophysiology of epilepsy [45,46].