We hypothesized that: (i) scores for food craving are higher in subjects with obesity compared to lean subjects; (ii) striatal DAT availability does not differ between subjects with obesity and lean subjects; and (iii) food craving scores are negatively associated with striatal DAT availability, particularly based on previous observations as described above [8,29,30]. The gene discussed is SLC6A3; the disease is obesity due to melanocortin 4 receptor deficiency.