ALDH2 and Cognitive impairment: No evidence was found for a causal association of cognitive impairment for rs1229984 in Alcohol Dehydrogenase 1B (ADH1B) [5,6] (Almeida et al. 2014, Kumari M et al. 2014) or rs671 in Alcohol Dehydrogenase 2 (ALDH2) [7] in the normal population [8].