OXT and attention deficit-hyperactivity disorder: Pharmacological treatments, especially with MPH, through a direct modulation of central dopaminergic and noradrenergic transmission in cortex and striatum, an indirect action on other neuropeptides such as oxytocin, and by regulating neural activity in these systems acting on top-down and only partly on bottom-up circuits [90], can concurrently improve empathy, theory of mind, executive and emotional regulation in youths with ADHD (see Figure 2).