Drug resistance of first/second-line anti-tuberculosis drugs (RIF, INH, EMB, OFX, and STR) was significantly related to the reported mutations of gene locus (rpoB, katG, inhA, embB, gyrA, and rpsL) in M. tb, but there were still differences in the location and frequency of these gene mutations in different regions. Here, INHA is linked to tuberculosis.