ZBP1 and Friedreich ataxia: In the cytosolic DNA-sensing pathway (Figure 4C), the upstream DEG ZBP1, the midstream IRF3 (interferon regulatory factor 3), the IRF7 (interferon regulatory factor 7), and the downstream IFNAR2 (interferon alpha and beta receptor subunit 2) were significantly and highly expressed in FA-treated groups compared with those in the corresponding control groups (p < 0.05).