Interestingly, several gained genes shared between at least two datasets were reported in the literature as overexpressed in high-grade gliomas, associated with poor prognosis, or in any case, involved in canonical pathways of GBM (EIF2AK1, FTL, SRC, GNG8, GNG11, GNG7, FZD9, GNB2, TGM2) [45,46,47,48,49]. The gene discussed is GNB2; the disease is central nervous system cancer.