The serum-induced expression of IL-1β mRNA in macrophages did not show significant differences at baseline (time 0) between overweight (n = 19, BMI: 28.0–29.9 kg/m2) and obese individuals (n = 17, BMI: 30.0–35.0 kg/m2), (median [IQR]: IL-1β in the overweight group vs. obesity: 2.55 [3.16–1.82] vs. 2.48 [2.79–2.10], Mann–Whitney test p = 0.791). The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.