TNFSF10 and neoplasm: Thus, as studies have suggested the benefit of combining other chemotherapies and TRAIL, we postulated that a pre-treatment using first-line chemotherapies such as cisplatin, 5-fluorouracil (5-FU) or vinorelbine, as a chemo-sensitizer, would lead to greater sensitivity of tumor cells and its CSCs to MSC-TRAIL-induced apoptosis, particularly in the TRAIL-resistant cells.