INS and cancer: In general, the majority of the dysregulated miRNAs were predicted to be involved in human diseases (mainly related to cancer), signal transduction (i.e., MAPK, ECM receptor interaction, etc.), cellular processes (i.e., regulation of actin cytoskeleton, focal adhesion, etc.), metabolism (i.e., fatty acid metabolism/biosynthesis, etc.), organismal systems (i.e., osteoclast differentiation, insulin signaling pathway), and to a small extent in genetic information processing (i.e., protein processing in endoplasmic reticulum).