Other human colon tumor samples paired with matched normal counterparts, which showed substantial alterations in the histological structure (Fig. S2B), also showed that both SIRT1 and SIRT1 phosphorylated on Ser serine 27 were upregulated in tumor tissues in most cases (Fig. 2G with the quantitative data in Fig. S2C and the absolute values in Fig. S2D), and their relationship was highly positive with a correlation coefficient of 0.7511 (Fig. S2E). Here, SIRT1 is linked to colonic neoplasm.