IFNA1 and systemic lupus erythematosus: Additional analyses revealed that blockade of IFN-α, but not other cytokines, restored the viability of neutrophils treated with SLE serum; conversely, the addition of IFN-α or autoantibodies from SLE serum compromised neutrophil viability, suggesting a role of IFN-α and immunoglobulin G (IgG) from SLE serum in mediating neutrophil death (Fig. 1).