Notably, evidence suggests that soluble oligomers of mutant ATXN1 correlate with disease progression (Lasagna-Reeves et al. 2015a, b) and are capable of seeding and propagation in a mouse model of SCA1 (Lasagna-Reeves et al. 2015b). The gene discussed is ATXN1; the disease is spinocerebellar ataxia type 1.