Interestingly, SIRT3 regulates proline synthesis by deacetylation of PYCR1 enzyme protein and increasing proline synthesis (Chen et al. 2019), and knockdown of PYCR1 in lung adenocarcinoma inhibits the proliferation and invasion by modulating JAK/STAT (Gao et al. 2020). The gene discussed is PYCR1; the disease is lung adenocarcinoma.