Supporting evidence has come from: unbiased metabolomics (Tang et al. 2018), dysregulation of proline enzymes associated with cancer (D’Aniello et al. 2020), maintenance or disruption of redox homeostasis (Schworer et al. 2020); signaling mechanisms for cell growth pathways (mTOR and AAR-ATF4) (D'Aniello et al. 2015), tumor suppressors (P53) (Donald et al. 2001), and oncogenes (MYC, PI3K-AKT) (Tang et al. 2018; Liu et al. 2015). Here, MYC is linked to cancer.