In the 2096 (4.3%) subjects with CKD Stage 3–5 (eGFR <60 mL/min/1.73 m2) at baseline, the prevalence of hypertension, age, and serum levels of biomarkers reflecting inflammation, myocardial injury, and left ventricular dysfunction (i.e. hs‐CRP, hs‐cTnI, and NT‐proBNP, respectively) were higher when compared to subjects with higher glomerular filtration rates. The gene discussed is NPPB; the disease is hypertensive disorder.