In order to evaluate the value of LINC00941 and LINC00514 as diagnostic markers for HCC, we detected the serum levels of LINC00941, LINC00514, and AFP in controls, CHB, LC and HCC populations, respectively, and evaluated the diagnostic value of LINC00941 and LINC00514 for HCC, LC, or CHB. This evidence concerns the gene AFP and hepatocellular carcinoma.