In our study, we detected the expression levels of LINC00941 and LINC00514 in the serum of controls, CHB, LC, and HCC patients, and found that compared with the healthy control group, the serum levels of LINC00941 and LINC00514 in the CHB, LC and HCC groups were significantly increased. Here, LINC00941 is linked to laryngotracheoesophageal cleft.