To assess the validated indexes’ diagnostic efficiency of sepsis, ROC curve analysis showed that the areas under ROC curve (AUC) of ApoC3, VCAM1, B2M, and ApoE were 0.625 (95%CI: 0.517–0.725), 0.679 (95%CI: 0.573–0.774), 0.581 (95%CI: 0.472–0.684), and 0.619 (0.510–0.719), respectively, and the AUC of PCT and CRP were 0.717 (95%CI: 0.612–0.807) and 0.706 (95%CI: 0.600–0.797), respectively.The AUC of validated indexes were lower than that of PCT and CRP, but there were no significant differences between each index and PCT or CRP (p > 0.05). The gene discussed is B2M; the disease is Sepsis.