With the exception of the atypical nuclear receptors dosage-sensitive sex reversal-adrenal hypoplasia congenital critical region on the X chromosome, gene 1 (DAX1, encoded by NR0B1) and small heterodimer partner (SHP, encoded by NR0B2), all other nuclear receptors share four to five common domains labeled A–F. This evidence concerns the gene NR0B2 and chronic primary adrenal insufficiency.