KCNJ11 and type 2 diabetes mellitus: The influxof Ca2+ ions drives a downstream cascadethat ultimately leads to insulin secretion from β-cells.16 Numerous mutations in either the Kir6.2 or SUR1subunits are linked to neonatal diabetes or congenital hyperinsulinism.17,18 Although SUs, known for the past 50 years, are still used in 25%of cases of T2DM treatment, they have many drawbacks.19 First of all, since their oral administration regime isbased on estimations and not on the actual level of the blood glucosemeasurements, SUs may provoke episodes of hyperinsulinemia.