ADORA2A and experimental autoimmune encephalomyelitis: Indeed, A2AR−/- mice developed more severe experimental autoimmune encephalomyelitis, and A2AR antagonism protects against experimental autoimmune encephalomyelitis (Mills et al., 2012); treatment with the A2AR agonist resulted in marked decreases in retinal inflammation in diabetic retinopathy (Ibrahim et al., 2011).