Previous studies from our lab and others showed that angiotensin converting enzyme-2 (ACE-2) is protective to lung cells in multiple disease conditions including pulmonary fibrosis and BPD.1,6–9 ACE-2 has been recently the focus in research as it acts as the receptor of SARS-CoV-2 virus causing the recent COVID-19 pandemic. This evidence concerns the gene ACE2 and pulmonary fibrosis.