AGT and idiopathic pulmonary fibrosis: Our previous studies showed that AngII mediates the profibrotic effect of hyperoxia on cultured human lung fibroblasts and that ACE-2, which protects against lung fibrosis in animal models by degrading AngII, is downregulated in the lungs of patients with Idiopathic Pulmonary Fibrosis through mechanisms yet to be fully identified.