CASP3 and neoplasm: As Figure 6 shows, the expression of all genes and the BAX/BCL2 ratio were significantly changed after CAP treatment in B16-F10 tumor cells in comparison to untreated controls (BAX (P = 0.028), BCL2 and CASP3 (P = 0.014), and BAX/BCL2 (P < 0.0001)).