In recent years, however, FPB has been shown to be an effective method also in biopsy-naïve patients who have moderate prostate-specific antigen (PSA) levels (<10 ng/ml) but have ongoing cancer suspicion. Thanks to FPB, although it varies according to the character of the lesion, up to 60% of cancer can be diagnosed [7-9]. Here, KLK3 is linked to cancer.