Studies have shown that the degree of glomerular sclerosis and the urine protein level are positively correlated with the upregulation of NOTCH1 expression in renal podocytes, and the upregulation of NOTCH1 in patients with chronic renal failure can aggravate the degree of interstitial fibrosis and the decline of glomerular filtration rate [19]. The gene discussed is NOTCH1; the disease is glomerulosclerosis.