PCSK9 and familial hyperaldosteronism: Inclisiran is a small interfering RNA (siRNA) molecule that blocks the hepatic production of PCSK9, thereby reducing LDL-C by 50% in patients with heterozygous FH.44 Its advantage compared with monoclonal inhibitors is its dosage, requiring only 2 to 3 injections per year instead of every 2 or 4 weeks with the latter.