This pathway represents a large family of serine/threonine kinases that, upon the reception of a stimuli, trigger a cascade of phosphorylation leading to specific cellular responses [12] and also plays a critical role in tumor progression and metastasis by induction of proteolytic enzymes that degrade the ECM (a key marker of invasion carcinoma), enhancement of cell migration, initiation of several prosurvival genes, and maintenance of tumor growth [13]. Here, MARK2 is linked to neoplasm.