As shown in the volcano plot (Supplementary Fig. 6b, c), SU decreased GZMB expression and upregulated genes related to inflammatory activation (FOS, JUN, NFKBIA, DUSP2, JAK1, PIM1), tumor immunity (CD47, PCBP2, EIF5A, PDIA3, EGR1), and DNA damage (H2AFX, DDIT3, GADD45B). The gene discussed is PDIA3; the disease is neoplasm.