H2AX and neoplasm: As shown in the volcano plot (Supplementary Fig. 6b, c), SU decreased GZMB expression and upregulated genes related to inflammatory activation (FOS, JUN, NFKBIA, DUSP2, JAK1, PIM1), tumor immunity (CD47, PCBP2, EIF5A, PDIA3, EGR1), and DNA damage (H2AFX, DDIT3, GADD45B).