The most prevalent causative gene for late-onset HL in this study was a mitochondrial m.3243A>G mutation, which was observed in 6 cases, followed by four cases with COCH gene variants, three cases each with CDH23, KCNQ4 and MYO6 variants, two cases with EYA4 variants, and one case each with ACTG1, COL9A3, GJB2, MYO7A, POU4F3, STRC, USH2A, and mitochondria m.1555A>G variants (Table 2). This evidence concerns the gene POU4F3 and Hodgkins lymphoma.