DCX and Alzheimer disease: While TgAPPsweOCN mice at 3-MO showed no difference in EdU+ and DCX+ cell densities compared to the controls, TgAPPsweOCN mice at 6-MO displayed significant reductions in EdU+ and DCX+ cell densities at both dorsal and ventral DG (Supplementary Fig. 6), demonstrating an age-dependent impairment in the hippocampal DG neurogenesis of TgAPPsweOCN mice, similar to that described in AD animal models32.