IL1B and Mental deterioration: Notice that Il1b was increased in the hippocampus but not the cortex of 12-MO TgAPPsweOCN mice (Supplementary Fig. 5g–h); and such IL-1β increase was accompanied by elevated Aβ42 and glial activation in the hippocampus, and cognitive decline behaviors (Supplementary Figs. 1b and 5 and Fig. 4g–i).