When cytokine and chemokine expression was compared between Asymptomatic, mild and severe COVID19, it was apparent that there was upregulation of pro-inflammatory cytokine/chemokine signaling pathways with downregulated AREG, IL18, IL18R1, IL18RAP, IL1R1, IL1R2, IL1RAP, IL6, PPBP and VEGFA gene expression. Here, IL1R1 is linked to COVID-19.