Comparison of severe and mild Symptomatic COVID-19 cases revealed an upregulation of CD177, the neutrophil marker, CXCL16, MAPKMAPK2 and IRF2BP2 with downregulation of ISGs; IFIT, IFIT3, OAS1, OAS2, LY6E and MX1 in severe cases. Here, CXCL16 is linked to COVID-19.