Anti-viral ISGs including, MAVS, OAS1, OAS2, OAS3, BST2, DHX58, IFNAR2, IRF2BP1, IRF4, MX1, PARP12, SAMD9L, SAMHD1, STAT2, TDR07, TRIM14, TRIM32, USP18, ZBP1, IRF4 and STAT showed marked downregulation in severe COVID-19. The gene discussed is SAMD9L; the disease is COVID-19.