Anti-viral ISGs including, MAVS, OAS1, OAS2, OAS3, BST2, DHX58, IFNAR2, IRF2BP1, IRF4, MX1, PARP12, SAMD9L, SAMHD1, STAT2, TDR07, TRIM14, TRIM32, USP18, ZBP1, IRF4 and STAT showed marked downregulation in severe COVID-19. Here, OAS3 is linked to COVID-19.