Oh and co-workers, combining resting-state functional MRI and DAT-PET with 18F-FP-CIT in 59 patients with clinically diagnosed PD, reported altered intrinsic functional activity of the right insular cortex that was correlated with decreased DAT availability in the caudate nucleus as well as with lower performance in executive, visuospatial and language tasks32. The gene discussed is SLC6A3; the disease is Parkinson disease.