In the animal component, immunization of normal mice with R. intestinalis and fecal microbiota transplantation in a murine model of spontaneous APS (NZW × BXSB) F1 induced an inflammatory reaction and cross-reactivity to beta-2-glycoprotein I. R. intestinalis is a trigger of APS. The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.