We carried out different cellular assay (MTT, mTFP reporter assay, wound healing assay, qRT-PCR, and western blotting) in which PIP-2 exhibited remarkable activities to stabilize the c-myc G4 DNA structure, accumulated in the nucleus, and downregulates the transcription and translation of c-myc gene and protein in human lung cancer cells (A549). Here, MYC is linked to lung carcinoma.