KEGG pathway enrichment analysis revealed that target proteins are involved in the MAPK, TNF, HIF-1, IL-17, PI3K, NF-kappa B, Toll-like receptor, and VEGF signaling pathways, AGE-RAGE signaling pathway in diabetic complications, pathways in cancer, proteoglycans in cancer, EGFR tyrosine kinase inhibitor resistance, cytokine–cytokine receptor interaction, and Alzheimer’s disease. Here, RENBP is linked to early-onset autosomal dominant Alzheimer disease.