These findings are in line with studies showing correlations between the presence and severity of fatty liver/NAFLD (non-alcoholic fatty liver disease) and lowered hepatic content of BCAA23,24 and point to hepatic ERα as a valuable target for interventions to limit the dysmetabolism associated with women ageing and to the therapeutic potential of the *AA diet. Here, ESR1 is linked to metabolic dysfunction-associated steatotic liver disease.