AFF1 and acute lymphoblastic leukemia: Comparing differentially expressed genes in both the normal and leukemic setting, we found 72 genes that were significantly upregulated in at least one normal FL HSPC subpopulation and also in MLL-AF4 infant-ALL (~40% of all genes upregulated in MLL-AF4 infant-ALL compared to MLL-AF4 childhood-ALL) (Supplementary Fig. 2b and Supplementary Data 2).