Indeed, as demonstrated in Supplementary Fig. 4, the OsxCre;Stat3fl/+ mice did not show obvious dwarf phenotype which was the main phenotypic difference between AD-HIES patients and the conditional Stat3 knockout mice, but exhibited AD-HIES-like skeletal defects, including craniofacial malformation and osteoporosis. This evidence concerns the gene STAT3 and Alzheimer disease.