Interestingly, the human B-ALL subtypes that were enriched for proliferating pro-B, pre-BCRd, and preBCRi clusters, included the BCL2/MYC, IKZF1 N159Y, and KMT2A subtypes, which are all associated with high risk poor prognosis49–51 (Fig. 7a). Here, MYC is linked to acute lymphoblastic leukemia.