Moreover, GO analysis showed that Cdh1 and other abnormally expressed genes were enriched in the processes such as “Apoptotic cleavage of cellular proteins”, “Apoptosis”, “Tight junction assembly”, “Hippo signaling pathway”, “Pathways in cancer”, and “Negative regulation of cell differentiation” (Supplementary Data 3), which were highly related to the phenotypes of Helq−/− germ cells as we observed. The gene discussed is HELQ; the disease is cancer.