Therefore, it is believed that NF-κB can induce malignancy and antitumor immunity through simultaneous inflammation.197 Some factors regulated by STAT3 also play essential roles in the tumor microenvironment.105,198–200 When it was found that NF-κB and STAT3 in tumor cells were activated simultaneously, people connected the two.201 Among these factors, IL-6 is an important factor that links the NF-κB signaling pathway with STAT3. The gene discussed is NFKB1; the disease is neoplasm.