There are multiple pathways that promote the survival of CSCs in breast or colon cancer, which include IL-6-JAK1-STAT3, IL-6-JAK2-STAT3, hypoxia-inducible factor-1α-JAK1-STAT3, and retinol-binding protein 4-JAK2-STAT3.110. Here, JAK1 is linked to colonic neoplasm.