Resveratrol, a natural polyphenolic stilbenoid, is found in grapes, mulberries, peanuts, rhubarb, etc. At the molecular level, resveratrol targets inflammatory cytokines, nuclear factor-κB, sirtuin, adenosine monophosphate kinase, and antioxidant enzymes.517 Resveratrol regulates immune responses by suppressing the phosphorylation of STAT1, STAT3, and NF-κB signaling pathways.518 In leukemia (Jurkat, SUP-B15, and Kasumi-1 cell lines), resveratrol inhibited IL-6-mediated STAT3 activation, induced apoptosis, and cell cycle arrest. This evidence concerns the gene STAT3 and leukemia.