Itacitinib: Itacitinib (INCB039110) is a selective JAK1 inhibitor that has exhibited efficacy in preclinical studies of arthritis, IBD, and aGVHD.427 Moreover, itacitinib dose-dependently reduced the levels of multiple cytokines common to CRS during CAR-T therapy. This evidence concerns the gene JAK1 and inflammatory bowel disease.