Catechins affect multiple signal pathways, such as JAK/STAT, MAPK, PI3K/AKT, Wnt, and Notch.526 Catechins exhibited the chemoprotective effect during cancer therapy, partly due to inhibiting STAT1 and STAT3, then decreasing the expression of iNOS and ICAM-1.527. The gene discussed is STAT3; the disease is cancer.