FLLL32 inhibited PD-L1 expression, decreased the number of Treg cells, and promoted Th1-protective immune responses.515 Besides, FLLL32 inhibited STAT3 phosphorylation induced by IFNα and IL-6 in breast cancer cells and retarded tumor growth in chicken embryo and mouse models.516. The gene discussed is IFNA1; the disease is breast carcinoma.