These derivatives inhibit STAT3 phosphorylation at Tyr705 and induce caspase-dependent apoptosis of melanoma cells without abrogating IFNγ-induced STAT1 phosphorylation or gene expression.514 HCT-15 cells were co-cultured with lymphocytes from 20 stage III colon cancer patients/healthy donors. The gene discussed is STAT3; the disease is malignant colon neoplasm.