LINC00346, an intergenic lncRNA located on chromosome 13q34, is upregulated in HCC and promotes tumor cell growth by decreasing the cell apoptosis rate and increasing the cell proliferation rate, which depends on the level of LINC00346 and the activated JAK/STAT signaling pathway.265 The phosphorylated transcription factor STAT3 significantly contributes to cancer growth and recurrence. The gene discussed is STAT3; the disease is hepatocellular carcinoma.