STAT3 and pancreatic neoplasm: LLL12 has shown promise for use in clinical settings.486–491 Recently, a study showed that XZH-5 blocks STAT3 phosphorylation at Try705, and inhibition of STAT3 signaling by XZH-5 could induce the apoptosis of human breast and pancreatic cancer cells.492 OPB-31121 inhibited both constitutively activated and IL-6-induced STAT3 activation in gastric cancer models.