Hypermethylation of SOCS3 has been found in multiple malignant diseases, such as lung cancer, head and neck cancer, and prostate cancer.260–262 Niwa et al. reported that 33.3% of HCC tissues exhibited hypermethylated SOCS3.263 Furthermore, long noncoding RNA promotes HCC progression,264 most likely via activation of the JAK/STAT pathway. The gene discussed is SOCS3; the disease is head and neck cancer.