STAT3 and neoplasm: STAT3 can function in a series of signal transduction processes, such as membrane binding, phosphorylation, and nuclear translocation through a cycle of palmitoylation–depalmitoylation, thereby regulating the differentiation of Th17 cells.100 STAT3 also promotes the immunosuppression of tumor-associated macrophages and myeloid-derived suppressor cells.101,102 Excessive activation of STAT3 is related to immunosuppression and transformation.103,104 (2) Regulation of cell growth, differentiation, and apoptosis.