Moreover, JAK1 and JAK3 are related to Th1 cell activation in the acute phase of atopic dermatitis.295 Multiple studies have shown that STAT6 exerts a significant effect on the immune response by regulating B-cell differentiation and contributing to IgE class switching.296 Therefore, STAT6 is a potent transductor and activator in allergic disorders. The gene discussed is IGHE; the disease is atopic eczema.