Notably, for the common astroependymal-like and NSC-like subpopulations, although we revealed more cancer type-specific druggable vulnerabilities across cancer subtypes, the shared candidates, including the transcription factor gene EEF1A1 and the kinase gene CCNL1, might help unify the pharmacological treatment of spinal ependymomas (Fig. 4g). Here, EEF1A1 is linked to cancer.