DNMT1 and obesity due to melanocortin 4 receptor deficiency: Intriguingly, our parallel study involving another genetic model D1KO mice with brown adipocyte-specific Dnmt1 deletion revealed that D1KO mice strikingly mimicked UTXKO mice in their myocyte-like brown fat remodeling, as well as in metabolic phenotypes of their susceptibility to diet-induced obesity, suggesting that both UTX and DNMT1 are involved in regulating BAT-myocyte remodeling in brown adipocytes.