In addition, we also found that whereas mice with mature brown adipocyte-specific deletion of Utx using the Ucp1-Cre exhibited a BAT-to-myocyte remodeling and were prone to diet-induced obesity, mice with Utx deletion in Myf5+-cells did not show any phenotypic differences when fed HFD, despite the fact that brown adipocytes derive from Myf5+ lineage precursors44. Here, MYF5 is linked to obesity due to melanocortin 4 receptor deficiency.