As coagulation process is intended for host to prevent dissemination of pathogenic bacteria,261 infection-induced type-I IFN serve as a crucial intermediator between innate immune response and coagulation.262 Induced by Gram-negative bacteria, LPS-mediated type-I IFN signaling amplify HMGB1 extracellular release via direct modification on acetylation levels at the nuclear location sequences. The gene discussed is HMGB1; the disease is infection.