IL18 and Sepsis: Ample evidences detected pyroptosis activities and elevated IL-18/IL-1β levels in neutrophils observed in LPS- and cecal ligation and puncture (CLP)-induced sepsis models.50 Serum PCR array performed on clinical sepsis patients also proved the presence of an altered inflammasome-related gene profile, featured with a greater magnitude of altered genes and higher intensity of gene expression disturbance compared to normal controls.