RIPK3 and Sepsis: Regarding its relationship with clinical outcome, lower levels of TRAIL, a potent inducer of apoptosis, is associated with increased levels of RIPK3, while RIPK3 levels is positively associated with higher incidence of organ dysfunction and septic shock, suggesting the pathological impacts of RIPK3-mediated pathways.102 In analog, in vivo sepsis studies have also proven the participation of RIPK3 necroptosis during organ deterioration.103