ANGPT2 and Sepsis: It specifically targets on the deleterious Ang2 clusters by converting it into a high molecular complex that bind and act as agonist of Tie2.377 Tie2 activation protect sepsis progression by strengthening the endothelial glycocalyx, amelioration of cytokine storm, and vascular leakage in targeted organs.377 Other compounds such as rh-Ang1 variant (COMP-Ang1, MAT.Ang1), inhibitors of VE-PTP (AKB-9778), and synthetic Tie2 agonist (Vasculotide) directly modified the functional state of their reciprocal targets so as to preserve endothelial barrier integrity.374,378–380