Rh-Ang1 protein is capable to prevent pulmonary capillary leakage and preserve integrity of blood–brain barrier (BBB) after intravenous administration.374,375 Rosiglitazone, a PPAR-γ agonist that result in higher brain and plasma levels of Ang1 and lower Ang2/Ang1 ratios, is able to restore BBB integrity, achieve better neurocognitive outcomes, and improved survivals in malaria-infected mice.376. The gene discussed is ANGPT1; the disease is malaria.