Mechanistically, ALK/EGFR binding was shown to trigger AKT-dependent STING activation in innate immune cells and provided evidence for a novel signaling pathway that have contributed to sepsis pathogenesis and septic shock (Fig. 1).359 In summary, ALK-EGFR-AKT pathway was proven as a critical modulator of lethal STING-mediated innate immune responses. This evidence concerns the gene ALK and Sepsis.