OXT and bipolar disorder: Therefore, to explore the role of the oxytocin system in the shared genetic liability between schizophrenia, bipolar disorder, T2D, and cardiovascular risk factors, we calculated the genetic contribution of oxytocin-pathway single-nucleotide polymorphisms (SNPs) to polygenic risk for schizophrenia and bipolar disorder, as well as T2D, to analyze and compare central and peripheral contributions and their associations with anthropometric and behavioral CVD risk factors.