The PPI network constructed by common targets showed that many key proteins of biological pathways are involved in the herbal therapeutic processes in glaucoma, such as AKT1 (core protein of PI3K/AKT signaling), TP53 (a tumor suppressor gene coding tumor protein P53), STAT3 (core protein of JAK/STAT signaling), IL6 and IL1B (proinflammatory factors). This evidence concerns the gene AKT1 and glaucoma.