Consistent with these studies, we observed a significantly longer OS in HNSCC patients with highly infiltrated immune cells and high percentage of PD1+, PDL1+, CD8+, CD68+, CD68 + PDL1+, CD57+, CD57 + PDL1+ and CD57 + PD1+ cells. The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.