The elevated levels of cPLA2α in familial and sporadic ALS [13] together with the observations that inclusions containing misfolded SOD1 are regularly present in motor neurons of ALS patients, both with and without SOD1 mutations [35], support the notion that misfolded SOD1 accumulated in the motor neurons contributes to the elevated cPLA2α expression. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.